Nitric oxide stress resistance in Porphyromonas gingivalis is mediated by a putative hydroxylamine reductase.

HcpR of Porphyromonas gingivalis is required for growth under nitrosative stress and survival within host cells.

Although the Gram-negative, anaerobic periodontopathogen Porphyromonas gingivalis must withstand nitrosative stress, which is particularly high in the oral cavity, the mechanisms allowing for protection against such stress are not known in this organism. In this study, microarray analysis of P. gingivalis transcriptional response to nitrite and nitric oxide showed drastic upregulation of the PG...

Porphyromonas gingivalis Synthase Demonstrate Impaired Killing of Mice Lacking Inducible Nitric Oxide

Improvement of Tissue Survival of Skin Flaps by 5α-Reductase Inhibitors: Possible Involvement of Nitric Oxide and Inducible Nitric Oxide Synthase

Background: Skin flap grafting is a popular approach for reconstruction of critical skin and underlying soft tissue injuries. In a previous study, we demonstrated the beneficial effects of two 5α-reductase inhibitors, azelaic acid and finasteride, on tissue survival in a rat model of skin flap grafting. In the current study, we investigated the involvement of nitric oxide and inducible nitric o...

Ghrelin-induced cSrc activation through constitutive nitric oxide synthase-dependent S-nitrosylation in modulation of salivary gland acinar cell inflammatory responses to Porphyromonas gingivalis

A peptide hormone, ghrelin, recognized for its role in the regulation of nitric oxide production has emerged as an important modulator of oral mucosal inflammatory responses to periodontopathic bacterium, P. gingivalis. As cSrc kinase plays a major role in controlling the activity of nitric oxide synthase (NOS) system, in this study we investigated the influence of P. gingivalis LPS on the proc...

An Investigation of Antibiotic Resistance of Aggregatibacter Actinomycetemcomitans and Porphyromonas Gingivalis in Peri-implantitis Lesions

Background and Aim: It has been shown that anaerobic and capnophilic bacteria play an important role in implant failure and loss. The present study is an in vitro research aimed to investigate the antibiotic resistance of Aggregatibacter actinomycetemcomi-tans (Aa) and Porphyromonas gingivalis (Pg) in peri-implantitis lesions of Iranian pa-tients and to find laboratory efficiency of some antibi...